2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogs

A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydroch...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 26; no. 4; pp. 580 - 585
Main Authors:	Deana, A. A, Stokker, G. E, Schultz, E. M, Smith, R. L, Cragoe, E. J, Russo, H. F, Watson, L. S
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-04-1983
Subjects:	Amines - pharmacology Animals Benzylamines - chemical synthesis Benzylamines - pharmacology Diuresis - drug effects Diuretics - chemical synthesis Dogs Rats Sodium Chloride - urine Structure-Activity Relationship
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.
Bibliography:	ark:/67375/TPS-QCGV5608-2 istex:1ADD8009B5544442D18A7E48679A0F1A5E6B0625 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00358a023