An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists

An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists

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Bibliographic Details
Published in:Journal of organic chemistry Vol. 65; no. 8; pp. 2615 - 2618
Main Authors: Lewis, Richard T, Ladduwahetty, Tamara, Merchant, Kevin J, Keown, Linda E, Hitzel, Laure, Verrier, Hugh, Stevenson, Graeme I, MacLeod, Angus M
Format: Journal Article
Language:English
Published: United States American Chemical Society 21-04-2000
Subjects:
Alcohols - chemical synthesis
Calorimetry
Diazonium Compounds - chemistry
Magnetic Resonance Spectroscopy
Oxazoles - chemical synthesis
Piperidines - chemical synthesis
Piperidines - pharmacology
Stereoisomerism
Substance P - antagonists & inhibitors
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Author Hitzel, Laure
Merchant, Kevin J
Verrier, Hugh
Stevenson, Graeme I
MacLeod, Angus M
Ladduwahetty, Tamara
Lewis, Richard T
Keown, Linda E
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  surname: Merchant
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  surname: Stevenson
  fullname: Stevenson, Graeme I
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crossref_primary_10_1016_j_tetlet_2005_08_148
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SubjectTerms Alcohols - chemical synthesis
Calorimetry
Diazonium Compounds - chemistry
Magnetic Resonance Spectroscopy
Oxazoles - chemical synthesis
Piperidines - chemical synthesis
Piperidines - pharmacology
Stereoisomerism
Substance P - antagonists & inhibitors
Title An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists
URI http://dx.doi.org/10.1021/jo9918246
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