An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists

An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists

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Bibliographic Details
Published in:Journal of organic chemistry Vol. 65; no. 8; pp. 2615 - 2618
Main Authors: Lewis, Richard T, Ladduwahetty, Tamara, Merchant, Kevin J, Keown, Linda E, Hitzel, Laure, Verrier, Hugh, Stevenson, Graeme I, MacLeod, Angus M
Format: Journal Article
Language:English
Published: United States American Chemical Society 21-04-2000
Subjects:
Alcohols - chemical synthesis
Calorimetry
Diazonium Compounds - chemistry
Magnetic Resonance Spectroscopy
Oxazoles - chemical synthesis
Piperidines - chemical synthesis
Piperidines - pharmacology
Stereoisomerism
Substance P - antagonists & inhibitors
Online Access:Get full text
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Bibliography:ark:/67375/TPS-3WQM9GX1-K
istex:F85201FA0EEB16E4EF073F3DDA35AF805F28DCB6
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo9918246