Phytotoxic and Nematicidal Components of Lavandula luisieri

• Published in: Journal of natural products (Washington, D.C.) Vol. 79; no. 2; pp. 261 - 266
• Main Authors: Julio, Luis F, Barrero, Alejandro F, Herrador del Pino, M. Mar, Arteaga, Jesús F, Burillo, Jesús, Andres, Maria Fe, Díaz, Carmen E, González-Coloma, Azucena
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society and American Society of Pharmacognosy 26-02-2016
• Subjects: Animals; Anti-Infective Agents - pharmacology; Antinematodal Agents - chemistry; Antinematodal Agents - isolation & purification; Antinematodal Agents - pharmacology; Aphids - drug effects; Lavandula - chemistry; Molecular Structure; Monoterpenes; Nuclear Magnetic Resonance, Biomolecular; Oils, Volatile - analysis; Plant Components, Aerial - chemistry; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Spain; Spodoptera - drug effects; Terpenes - chemistry; Terpenes - isolation & purification; Terpenes - pharmacology; Triterpenes - isolation & purification; Ursolic Acid; Spain
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/acs.jnatprod.5b00501

Several preparations were obtained from the aerial parts of predomesticated Lavandula luisieri, including the essential oil and ethanolic, hexane, and ethyl acetate extractives. Additionally, pilot plant vapor pressure extraction was carried out at a pressure range of 0.5–1.0 bar to give a vapor pressure oil and an aqueous residue. A chemical study of the hexane extract led to the isolation of six necrodane derivatives (1, 2, and 4–7), with four of these (1, 2, 5, and 7) being new, as well as camphor, a cadinane sesquiterpene (9), tormentic acid, and ursolic acid. The EtOAc and EtOH extracts contained a mixture of phenolic compounds with rosmarinic acid being the major component. Workup of the aqueous residue resulted in the isolation of the necrodane 3 and (1R*,2S*,4R*)-p-menth-5-ene-1,2,8-triol (8), both new natural compounds. The structures of the new compounds were established based on their spectroscopic data. The phytotoxic and nematicidal activities of these compounds were evaluated.