Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification o...

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 74; no. 9; pp. 1965 - 1971
Main Authors:	Rateb, Mostafa E, Houssen, Wael E, Harrison, William T. A, Deng, Hai, Okoro, Chinyere K, Asenjo, Juan A, Andrews, Barbara A, Bull, Alan T, Goodfellow, Michael, Ebel, Rainer, Jaspars, Marcel
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society and American Society of Pharmacognosy 23-09-2011
Subjects:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacillus subtilis - drug effects Cinnamates - chemistry Cinnamates - isolation & purification Escherichia coli - drug effects Hygromycin B - analogs & derivatives Hygromycin B - chemistry Hygromycin B - isolation & purification Listeria monocytogenes - drug effects Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Metabolome Microbial Sensitivity Tests Molecular Structure Staphylococcus aureus - drug effects Streptomyces Streptomyces - chemistry Streptomyces - genetics Streptomyces - metabolism Vibrio - drug effects
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Summary:	The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A–C (1–3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1–3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np200470u