Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary carbon stereocenter is currently of great interest because such privileged 3D structures are widely present in natural products that exhibit a broad spectrum of biological and pharmacological activities. Th...

Full description

Saved in:

Bibliographic Details
Published in:	ACS catalysis Vol. 9; no. 3; pp. 1820 - 1882
Main Authors:	Xu, Peng-Wei, Yu, Jin-Sheng, Chen, Chen, Cao, Zhong-Yan, Zhou, Feng, Zhou, Jian
Format:	Journal Article
Language:	English
Published:	American Chemical Society 01-03-2019
Subjects:	organocatalysis catalytic enantioselective spiro quaternary carbon stereocenters reaction mechanism metal catalysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary carbon stereocenter is currently of great interest because such privileged 3D structures are widely present in natural products that exhibit a broad spectrum of biological and pharmacological activities. This review summarizes the advances based on six major synthetic strategies and showcases the reaction mechanisms in detail. The advantages and limitations of each synthetic strategy are presented, and the remaining synthetic opportunities are outlined.
ISSN:	2155-5435 2155-5435
DOI:	10.1021/acscatal.8b03694