Visible-Light Photoredox-Catalyzed Divergent 1,2-Diacylation and Hydroacylation of Alkenes with Carboxylic Acid Anhydride

Visible-Light Photoredox-Catalyzed Divergent 1,2-Diacylation and Hydroacylation of Alkenes with Carboxylic Acid Anhydride

A photoredox-catalyzed divergent 1,2-dicarbonylation and hydroacylation of alkenes with acid anhydride is presented. This approach offers a mild and efficient entry to 1,4-dicarbonyl compounds bearing all-carbon quaternary centers, exhibiting a broad substrate scope and high functional group compati...

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Bibliographic Details
Published in:Organic letters Vol. 25; no. 28; pp. 5268 - 5272
Main Authors: Zhou, Youkang, Zhao, Lirong, Hu, Mingyou, Duan, Xin-Hua, Liu, Le
Format: Journal Article
Language:English
Published: United States American Chemical Society 21-07-2023
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Summary:A photoredox-catalyzed divergent 1,2-dicarbonylation and hydroacylation of alkenes with acid anhydride is presented. This approach offers a mild and efficient entry to 1,4-dicarbonyl compounds bearing all-carbon quaternary centers, exhibiting a broad substrate scope and high functional group compatibility. Hydrocarbonylaltion of alkenes can also be realized by simply introducing a proton source to the reaction system. Mechanism investigations support a radical addition/radical-polar crossover cascade.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c01787