Temperature-Responsive Properties and Drug Solubilization Capacity of Amphiphilic Copolymers Based on N-Vinylpyrrolidone and Vinyl Propyl Ether

• Published in: Langmuir Vol. 26; no. 10; pp. 7590 - 7597
• Main Authors: Zhunuspayev, Daulet E, Mun, Grigoriy A, Khutoryanskiy, Vitaliy V
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 18-05-2010
• Subjects: Chemistry; Colloidal state and disperse state; Exact sciences and technology; General and physical chemistry; Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites; Particle Size; Polymers - chemical synthesis; Polymers - chemistry; Pyrrolidinones - chemistry; Riboflavin - chemistry; Solubility; Surface physical chemistry; Surface Properties; Temperature; Vinyl Compounds - chemistry; Water - chemistry; Water; Drug; Critical property; Hydrocarbon; Ether; Light scattering; Solubility; Temperature effect; Hydrophobicity; Solubilization; Condensed benzenic compound; Free radical; Gel permeation chromatography; Pyrene; Dynamics; Polarity; Copolymer; Aqueous solution; Critical temperature; Radical copolymerization; Chemical reactivity; Structure; Molecular mass
• ISSN: 0743-7463; 1520-5827
• DOI: 10.1021/la904403k

A series of amphiphilic copolymers were synthesized by free-radical copolymerization of N-vinylpyrrolidone (NVP) with vinyl propyl ether (VPE), and the structure of the copolymers was characterized by elemental analysis and gel permeation chromatography. The reactivity of VPE in copolymerization was found to be significantly lower than the reactivity of NVP, which resulted in a decrease of copolymers’ yields and molecular weights with higher content of VPE in the feed mixture. An investigation of the behavior of the copolymers in aqueous solutions at different temperatures by dynamic light scattering revealed the presence of lower critical solution temperature, which depending on the content of VPE ranged within 23−38 °C. Aqueous solutions of these copolymers were studied by fluorescent spectroscopy with pyrene as a polarity probe to reveal the formation of hydrophobic domains. The copolymers were found to be useful for enhancing the solubility of riboflavin in water.