Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides

Three new phenolic compounds, (E)-4′-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4−10). The structures of the new compounds (1−3) were deter...

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 72; no. 10; pp. 1895 - 1898
Main Authors:	Youn, Ui Joung, Lee, Ye Seul, Jeong, Hana, Lee, Jun, Nam, Joo-Won, Lee, Yoo Jin, Hwang, Eun Sook, Lee, Je-Hyun, Lee, Dongho, Kang, Sam Sik, Seo, Eun-Kyoung
Format:	Journal Article
Language:	English
Published:	Northbrook, IL American Chemical Society and American Society of Pharmacognosy 23-10-2009 American Society of Pharmacognosy
Subjects:	3T3-L1 Cells - drug effects Adipogenesis - drug effects Anemarrhena - chemistry Animals Biological and medical sciences Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology General pharmacology Korea Medical sciences Mice Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plants, Medicinal - chemistry Rhizome - chemistry Asia China Korea Monocotyledones Embryo Coumarine derivatives Ynone Oxygen heterocycle Diphenols Medicinal plant Folk medicine Angiospermae Rhizome Bicyclic compound Aromatic compound Inhibition Below ground plant part Pharmacognosy Rodentia Lactone Cell differentiation In vitro Biological activity Vertebrata Liliaceae Mammalia Ketophenols Cell line Mouse Plant origin Phenols Benzenic compound Isolation Preadipocyte Spermatophyta Structural analysis
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Summary:	Three new phenolic compounds, (E)-4′-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4−10). The structures of the new compounds (1−3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np900397f