Expedient and Rapid Synthesis of 1,2,3-Triazolo[5,1-c]morpholines through Palladium−Copper Catalysis

A one-pot approach using palladium−copper as catalyst has been developed for the synthesis of morpholines fused with 1,2,3-triazole. Good regioselectivity, mild reaction conditions, high yields and short reaction time are the hallmarks of this method.

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Bibliographic Details
Published in:	Journal of organic chemistry Vol. 74; no. 9; pp. 3612 - 3615
Main Authors:	Chowdhury, Chinmay, Mukherjee, Sanjukta, Das, Bimolendu, Achari, Basudeb
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-05-2009
Subjects:	Azides - chemistry Catalysis Catalysts: preparations and properties Chemistry Copper - chemistry Exact sciences and technology General and physical chemistry Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Kinetics Morpholines - chemical synthesis Morpholines - chemistry Organic chemistry Palladium - chemistry Preparations and properties Stereoisomerism Substrate Specificity Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry Triazoles - chemical synthesis Triazoles - chemistry Regioselectivity Organic azide Mild operating conditions Transition metal Palladium Morpholine derivatives Copper ion Catalysis Copper Chemical synthesis Platinoid Catalyst Oxygen nitrogen heterocycle
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Description
Summary:	A one-pot approach using palladium−copper as catalyst has been developed for the synthesis of morpholines fused with 1,2,3-triazole. Good regioselectivity, mild reaction conditions, high yields and short reaction time are the hallmarks of this method.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo900428j