Actinomycin D as an Epimutagen in Protists

A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as...

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Bibliographic Details
Published in:	Acta Protozoologica Vol. 56; no. 3; pp. 139 - 147
Main Authors:	Uspenskaya, Zoya I, Yudin, Alexander L
Format:	Journal Article
Language:	English
Published:	Warsaw Jagiellonian University Press 01-01-2017 Jagiellonian University-Jagiellonian University Press
Subjects:	Amoeba proteus Antibiotics Cloning Cytoplasm Deoxyribonucleic acid Dileptus anser DNA Epigenetics Ethanol Experiments Genetic research Hypotheses Laboratories Mutation Protists New York United States > US Dileptus anser actinomycin D epigenetic variation epimutagen Amoeba proteus inheritable destabilization of characters
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Summary:	A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.
ISSN:	0065-1583 1689-0027
DOI:	10.4467/16890027AP.17.012.7493