Chemical Nematicides: Recent Research Progress and Outlook

• Published in: Journal of agricultural and food chemistry Vol. 68; no. 44; pp. 12175 - 12188
• Main Authors: Chen, Jixiang, Li, Qing X, Song, Baoan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04-11-2020
• Subjects: Animals; Antinematodal Agents - chemical synthesis; Antinematodal Agents - chemistry; Antinematodal Agents - pharmacology; Drug Design; Nematoda - drug effects; Nematoda - physiology; Plant Diseases - parasitology; Structure-Activity Relationship; mechanism of action; new target; active fragment; nematicides; nematicidal
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.0c02871

Plant-parasitic nematodes have caused huge economic losses to agriculture worldwide and seriously threaten the sustainable development of modern agriculture. Chemical nematicides are still the most effective means to manage nematodes. However, the long-term use of organophosphorus and carbamate nematicides has led to a lack of field control efficacy and increased nematode resistance. To meet the huge market demand and slow the growth of resistance, new nematicides are needed to enter the market. The rational design and synthesis of new chemical scaffolds to screen for new nematicides is still a difficult task. We reviewed the latest research progress of nematicidal compounds in the past decade, discussed the structure–activity relationship and mechanism of action, and recommended some nematicidal active fragments. It is hoped that this review can update the recent progress on nematicide discoveries and provide new ideas for the design and mechanism of action studies of nematicides.