Mineralized Porphyrin Metal–Organic Framework for Improved Tumor Elimination and Combined Immunotherapy

• Published in: ACS nano Vol. 17; no. 13; pp. 12471 - 12482
• Main Authors: Yu, Yun, Xie, Bo-Ru, Liu, Xin-Hua, Ye, Jing-Jie, Zhong, Zhenlin, Zhang, Xian-Zheng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11-07-2023
• Subjects: Animals; Calcium; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Immunotherapy; Mammary Neoplasms, Animal; Metal-Organic Frameworks - pharmacology; Mice; Neoplasms - therapy; immunogenic death; cancer therapy; calcium ion therapy; adjuvant; antimetastasis
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.3c02126

Calcium ion therapy is a potential anticancer treatment. However, the cellular calcium-buffering mechanism limited the effectiveness of calcium ion therapy. Here, we constructed a mineralized porphyrin metal–organic framework (PCa) to produce calcium ions and reactive oxygen species (ROS), which destroyed cell calcium buffering capacity and amplified the cell damage caused by calcium overload. In addition, PCa could induce cell immunogenic death to release tumor-associated antigen (TAA) and be used as an adjuvant. Thus, PCa could increase DC maturation and promote the antitumor activity of CD8+ T cells. For mice experiment, PCa not only showed excellent tumor elimination on the subcutaneous breast tumor but also achieved obvious antimetastasis effect in the metastatic tumor model. This nanosystem could eliminate the primary tumor and boost effective antitumor immunotherapy for comprehensive anticancer treatment.