Multicomponent Synthesis of 1‑Aryl 1,2,4-Triazoles

A multicomponent (single reactor) process for the synthesis of 1-aryl 1,2,4-triazoles was explored and developed. This transformation prepared the 1,2,4-triazole directly from anilines, amino pyridines, and pyrimidines. The reaction scope was explored with 21 different substrates, and the position o...

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Bibliographic Details
Published in:	Organic letters Vol. 15; no. 14; pp. 3586 - 3589
Main Authors:	Tam, Annie, Armstrong, Ian S, La Cruz, Thomas E
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 19-07-2013
Subjects:	Aniline Compounds - chemistry Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Magnetic Resonance Spectroscopy Pyrimidines - chemistry Triazoles - chemical synthesis Triazoles - chemistry
Online Access:	Get full text
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Summary:	A multicomponent (single reactor) process for the synthesis of 1-aryl 1,2,4-triazoles was explored and developed. This transformation prepared the 1,2,4-triazole directly from anilines, amino pyridines, and pyrimidines. The reaction scope was explored with 21 different substrates, and the position of the nitrogen atoms in the newly formed ring was established by 15N labeling and NMR spectroscopy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol401428x