Antimycobacterial Labdane Diterpenes from Leucas stelligera

• Published in: Journal of natural products (Washington, D.C.) Vol. 76; no. 10; pp. 1836 - 1841
• Main Authors: Kulkarni, Roshan R, Shurpali, Ketaki, Puranik, Vedavati G, Sarkar, Dhiman, Joshi, Swati P
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society and American Society of Pharmacognosy 25-10-2013
• Subjects: Antitubercular Agents - chemistry; Antitubercular Agents - isolation & purification; Antitubercular Agents - pharmacology; Crystallography, X-Ray; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; Drug Screening Assays, Antitumor; Flavones - chemistry; Flavones - isolation & purification; Hep G2 Cells; Humans; India; Inhibitory Concentration 50; Lamiaceae - chemistry; Microbial Sensitivity Tests; Molecular Conformation; Molecular Structure; Mycobacterium tuberculosis - drug effects; Nuclear Magnetic Resonance, Biomolecular; India
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np400002p

Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1–4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using 1D and 2D NMR spectroscopic data and single-crystal X-ray crystallography of compound 1. Compounds 1–4 exhibited selective antimycobacterial activity against Mycobacterium tuberculosis with IC50 values in the range 5.02–9.80 μg/mL.