A Concise Total Synthesis of Naamidine A

A Concise Total Synthesis of Naamidine A

A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect to the preparation of analogues. Formation of the 2-aminoimidazole core is achieved by condensation of the appropriate α-aminoketone with cyan...

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Bibliographic Details
Published in:Organic letters Vol. 8; no. 3; pp. 419 - 421
Main Authors: Aberle, Nicholas S, Lessene, Guillaume, Watson, Keith G
Format: Journal Article
Language:English
Published: United States American Chemical Society 02-02-2006
Subjects:
Animals
Biological Products - chemical synthesis
Imidazoles - chemical synthesis
Molecular Structure
Porifera - chemistry
Online Access:Get full text
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Summary:A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect to the preparation of analogues. Formation of the 2-aminoimidazole core is achieved by condensation of the appropriate α-aminoketone with cyanamide.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol052568o