Preparation and Characterization of Cholic Acid-Derived Antimicrobial Agents with Controlled Stabilities

Novel cholic acid-derived antimicrobial agents that decompose under mildly basic conditions have been prepared. These compounds range in biological properties from potent antibacterial activity to effective permeabilization of the outer membranes of Gram-negative bacteria.

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Bibliographic Details
Published in:	Organic letters Vol. 2; no. 18; pp. 2837 - 2840
Main Authors:	Guan, Qunying, Li, Chunhong, Schmidt, Erica J, Boswell, J. Scott, Walsh, Joshua P, Allman, Glenn W, Savage, Paul B
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 07-09-2000
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Cell Membrane Permeability Cholic Acids - chemical synthesis Cholic Acids - pharmacokinetics Cholic Acids - pharmacology Drug Stability Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - metabolism Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - metabolism Microbial Sensitivity Tests Structure-Activity Relationship
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Description
Summary:	Novel cholic acid-derived antimicrobial agents that decompose under mildly basic conditions have been prepared. These compounds range in biological properties from potent antibacterial activity to effective permeabilization of the outer membranes of Gram-negative bacteria.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0062704