Cu(I)-Catalyzed Three-Component Cyclization for the Construction of Functionalized Thiazoles
A novel and straightforward strategy for the synthesis of functionalized thiazoles from thioamides, ynals, and alcohols via a copper(I)-catalyzed three-component reaction has been described. Through the formation of new C–S, C–N, and C–O bonds in one pot, it is easy to produce various valuable thia...
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| Published in: | Journal of organic chemistry Vol. 85; no. 15; pp. 10118 - 10124 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
American Chemical Society
07-08-2020
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| Online Access: | Get full text |
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| Summary: | A novel and straightforward strategy for the synthesis of functionalized thiazoles from thioamides, ynals, and alcohols via a copper(I)-catalyzed three-component reaction has been described. Through the formation of new C–S, C–N, and C–O bonds in one pot, it is easy to produce various valuable thiazoles fixed with aryl or heteroaryl groups. In addition, the reaction also exhibits other unique advantages, such as high step economics, good functional group tolerance, and good regioselectivity. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.0c01381 |