Enantioselective Epoxidation of β,γ-Unsaturated Carboxylic Acids by a Cooperative Binuclear Titanium Complex

Enantioselective Epoxidation of β,γ-Unsaturated Carboxylic Acids by a Cooperative Binuclear Titanium Complex

Enantioselective epoxidation of β,γ-unsaturated carboxylic acids with a cooperative binuclear titanium complex has been developed to provide single diastereomer γ-lactones in high yields and enantioselectivities via intramolecular cyclization. For the success of the reaction, the proper distance bet...

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Bibliographic Details
Published in:ACS catalysis Vol. 9; no. 4; pp. 3384 - 3388
Main Authors: Sawano, Takahiro, Yamamoto, Hisashi
Format: Journal Article
Language:English
Published: American Chemical Society 05-04-2019
Subjects:
unsaturated carboxylic acids
epoxidation
asymmetric catalysis
titanium
binuclear complex
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Summary:Enantioselective epoxidation of β,γ-unsaturated carboxylic acids with a cooperative binuclear titanium complex has been developed to provide single diastereomer γ-lactones in high yields and enantioselectivities via intramolecular cyclization. For the success of the reaction, the proper distance between the carboxylic acid and alkene is quite important, offering the regioselective epoxidation of unsaturated carboxylic acids bearing two similar alkenes.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.9b00840