Application of Crabtree/Pfaltz-Type Iridium Complexes for the Catalyzed Asymmetric Hydrogenation of an Agrochemical Building Block

Application of Crabtree/Pfaltz-Type Iridium Complexes for the Catalyzed Asymmetric Hydrogenation of an Agrochemical Building Block

Herein we report improved chemo- and enantioselective hydrogenations of 1-(2,2,4-trimethylquinolin-1­(2H)-yl)­ethan-1-one (1) toward (R)-1-(2,2,4-trimethyl-3,4-dihydroquinolin-1­(2H)-yl)­ethan-1-one (2) using well-defined novel Crabtree-type iridium complexes.

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Bibliographic Details
Published in:Organic process research & development Vol. 24; no. 3; pp. 443 - 447
Main Authors: Schneekönig, Jacob, Liu, Weiping, Leischner, Thomas, Junge, Kathrin, Schotes, Christoph, Beier, Christian, Beller, Matthias
Format: Journal Article
Language:English
Published: American Chemical Society 20-03-2020
Subjects:
iridium catalysis
asymmetric hydrogenation
catalyst design
unactivated olefins
N-heterocycles
alkene reduction
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Description
Summary:Herein we report improved chemo- and enantioselective hydrogenations of 1-(2,2,4-trimethylquinolin-1­(2H)-yl)­ethan-1-one (1) toward (R)-1-(2,2,4-trimethyl-3,4-dihydroquinolin-1­(2H)-yl)­ethan-1-one (2) using well-defined novel Crabtree-type iridium complexes.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.9b00466