Scalable Electrochemical Dehydrogenative Lactonization of C(sp2/sp3)–H Bonds

Scalable Electrochemical Dehydrogenative Lactonization of C(sp2/sp3)–H Bonds

A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C­(sp2/sp3)–H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly devel...

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Bibliographic Details
Published in:Organic letters Vol. 20; no. 1; pp. 252 - 255
Main Authors: Zhang, Sheng, Li, Lijun, Wang, Huiqiao, Li, Qian, Liu, Wenmin, Xu, Kun, Zeng, Chengchu
Format: Journal Article
Language:English
Published: United States American Chemical Society 05-01-2018
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Summary:A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C­(sp2/sp3)–H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly developed electrochemical process was demonstrated on a 40 g scale following an operationally simple protocol. The remote lactonization of C­(sp3)–H bonds would constitute an important synthetic advance toward electrochemical C–O bond formation.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03617