High Output Continuous Nitration
The design and use of a flow reactor for scaling up an exothermic nitration reaction in a safe manner on production scale is described. The flow reactor is made of a jacketed, stainless steel coil. Two charging methods, pump and nitrogen pressure were tested on a substituted pyridine substrate. The...
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| Published in: | Organic process research & development Vol. 16; no. 5; pp. 930 - 933 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
American Chemical Society
18-05-2012
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| Online Access: | Get full text |
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| Summary: | The design and use of a flow reactor for scaling up an exothermic nitration reaction in a safe manner on production scale is described. The flow reactor is made of a jacketed, stainless steel coil. Two charging methods, pump and nitrogen pressure were tested on a substituted pyridine substrate. The transfer from kilogram scale in the laboratory to 100-kg scale in the plant was successfully accomplished. |
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| ISSN: | 1083-6160 1520-586X |
| DOI: | 10.1021/op2003425 |