Particle Engineering Strategies via Crystallization for Pulmonary Drug Delivery
This review covers recent developments in the area of particle engineering via crystallization for pulmonary drug delivery. The past decade has witnessed a shift from empirical formulation efforts to an engineering approach based on a better understanding of the crystallization process. Microcrystal...
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| Published in: | Organic process research & development Vol. 13; no. 6; pp. 1215 - 1223 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
American Chemical Society
20-11-2009
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| Online Access: | Get full text |
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| Summary: | This review covers recent developments in the area of particle engineering via crystallization for pulmonary drug delivery. The past decade has witnessed a shift from empirical formulation efforts to an engineering approach based on a better understanding of the crystallization process. Microcrystals with nanoscale substructures can now be designed and their functionality has contributed significantly to the stability and efficacy of the particulate dosage form. This review provides concepts and a theoretical framework for particle design calculations. It reviews experimental research to identify variables that influence particle formation. It offers an explanation of how excipient properties in combination with process variables influence the morphology of the engineered particles. A wide range of pharmaceutical applications of large porous particles, particles with low surface energy, and particle aggregates, is discussed, with specific emphasis on the underlying crystal formation mechanism and design concepts. |
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| ISSN: | 1083-6160 1520-586X |
| DOI: | 10.1021/op900013a |