Glycogen Synthase Kinase 3β (GSK3β) Regulates Differentiation and Proliferation in Neural Stem Cells from the Rat Subventricular Zone

Glycogen Synthase Kinase 3β (GSK3β) Regulates Differentiation and Proliferation in Neural Stem Cells from the Rat Subventricular Zone

On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3β (GSK3β) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/β-catenin signaling pathway appear to...

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Bibliographic Details
Published in:Journal of proteome research Vol. 6; no. 3; pp. 1198 - 1208
Main Authors: Maurer, Martin H, Brömme, Jens O, Feldmann, Robert E, Järve, Anne, Sabouri, Fatemeh, Bürgers, Heinrich F, Schelshorn, Dominik W, Krüger, Carola, Schneider, Armin, Kuschinsky, Wolfgang
Format: Journal Article
Language:English
Published: American Chemical Society 01-03-2007
Online Access:Get full text
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Summary:On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3β (GSK3β) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/β-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of β-catenin target genes during GSK3β inhibition, associated with decreased apoptosis. Keywords: Neural stem cell • Neurosphere • Glycogen Synthase Kinase 3β • Two-dimensional gel electrophoresis • Rat • Subventricular zone
ISSN:1535-3893
1535-3907
DOI:10.1021/pr0605825