An Efficient and Impurity-Free Process for Telmisartan:  An Antihypertensive Drug

An Efficient and Impurity-Free Process for Telmisartan:  An Antihypertensive Drug

Telmisartan (1), a substituted dibenzimidazole derivative, is an antihypertensive drug, essentially used to control blood pressure. An improved, cost-effective, and impurity-free process for telmisartan (1) suitable for large-scale production is described here by addressing various process developme...

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Bibliographic Details
Published in:Organic process research & development Vol. 11; no. 1; pp. 81 - 85
Main Authors: Reddy, Kikkuru Srirami, Srinivasan, Neti, Reddy, Chinta Raveendra, Kolla, Naveenkumar, Anjaneyulu, Yerremilli, Venkatraman, Sundaram, Bhattacharya, Apurba, Mathad, Vijayavitthal T
Format: Journal Article
Language:English
Published: American Chemical Society 01-01-2007
Online Access:Get full text
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Summary:Telmisartan (1), a substituted dibenzimidazole derivative, is an antihypertensive drug, essentially used to control blood pressure. An improved, cost-effective, and impurity-free process for telmisartan (1) suitable for large-scale production is described here by addressing various process development issues. The overall yield obtained from this newly developed process is around 50% (over five steps) compared to the literature reported process (21%, over eight steps).
ISSN:1083-6160
1520-586X
DOI:10.1021/op060200g