Facile Synthesis of TiO2–SiO2–P2O5/CaO/ZnO with a Core–Shell Structure for Bone Implantation

• Published in: ACS omega Vol. 7; no. 50; pp. 46564 - 46572
• Main Authors: Lyutova, Ekaterina S., Tkachuk, Valeriya A., Selyunina, Liliya A., Borilo, Lyudmila P., Fedorishin, Dmitriy A., Chen, Yu-Wen
• Format: Journal Article
• Language: English
• Published: American Chemical Society 20-12-2022
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.2c05398

A facile synthesis method was developed to synthesize TiO2–SiO2–P2O5/CaO or TiO2–SiO2–P2O5/ZnO with a core–shell structure. The carboxylic cation exchanger Tokem-250 has a high selectivity for Ca2+/Zn2+ ions and was used in this study. The framework of the material in the shell was TiO2–SiO2–P2O5, and the inner part was filled with CaO (sample TiO2–SiO2/CaO) or ZnO (sample TiO2–SiO2–P2O5/ZnO). A stepwise heat treatment (drying in a drying oven at 60 °C for 30 min, then annealing in a muffle furnace for 30 min at 150, 250, and 350 °C, at 600 °C for 6 h, and at 800 °C for 1 h) was needed to obtain a homogeneous material. The poly­(vinyl alcohol) was used as a binding additive. The obtained composites were characterized by a regular structure and highly developed surface. The samples exhibit bioactive properties in the simulated body fluid (SBF) solution, since the surface contains active centers (Si4+, Ti4+) which contribute to mineralization and precipitation of the calcium-phosphate compounds on the surface from biological media. The TiO2–SiO2–P2O5/CaO-PVA samples did not exceed acceptable hemolysis levels for medical materials.