Proteinuria and nephrotic syndrome induced by renin in patients with renal artery stenosis

• Published in: Archives of internal medicine (1960) Vol. 140; no. 12; p. 1631
• Main Authors: Kumar, A, Shapiro, A P
• Format: Journal Article
• Language: English
• Published: United States 01-12-1980
• Subjects: Aged; Blood Pressure; Blood Vessel Prosthesis - methods; Constriction, Pathologic; Female; Humans; Hypertension, Renal - metabolism; Middle Aged; Nephrotic Syndrome - diagnosis; Nephrotic Syndrome - etiology; Proteinuria - diagnosis; Proteinuria - etiology; Renal Artery Obstruction - complications; Renal Artery Obstruction - surgery; Renin - blood
• ISSN: 0003-9926
• DOI: 10.1001/archinte.1980.00330230077017

Exacerbation of hypertension and a marked excretion of protein in the urine were observed in three patients in the absence of underlying renal parenchymal disease or other causes of proteinuria. Stenosis of a renal artery and hyperreninemia were present in all three patients. Correction of the stenosis by arterial bypass or nephrectomy resulted in a rapid decrease in urinary protein excretion. The relationship between the levels of renin activity and the proteinuria in one patient and long-term follow-up in the other two patients are reported, and the mechanisms of this proteinuria are reviewed. Renal artery stenosis may be the underlying cause in some cases of idiopathic nephrotic syndrome.