Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol + Water Mixtures at 298.2 K

• Published in: Journal of chemical and engineering data Vol. 55; no. 1; pp. 578 - 582
• Main Authors: Ali, Hany S. M, York, Peter, Blagden, Nicholas, Soltanpour, Shahla, Acree, William E, Jouyban, Abolghasem
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 14-01-2010
• Subjects: Antineoplastic agents; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; General aspects; Immunomodulators; Medical sciences; Pharmacology. Drug treatments; Antineoplastic agent; Steroid; Corticosteroid; Budesonide; Ethanol; Steroid hormone; Antiinflammatory agent; Prediction; Solubility; Alcohol; Hydrocortisone; Mixed solvent; Adrenal hormone; Models; Immunosuppressive agent; Hydroorganic solvent; Prednisolone; Physicochemical properties
• ISSN: 0021-9568; 1520-5134
• DOI: 10.1021/je900376r

Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum values of the volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities were also predicted by a previously established log−linear model of Yalkowsky with the OMRD of 53.8 %.