Enantioselective Henry Reaction Catalyzed by CuII Salt and Bipiperidine

• Published in: Journal of organic chemistry Vol. 75; no. 4; pp. 1313 - 1316
• Main Authors: Noole, Artur, Lippur, Kristin, Metsala, Andrus, Lopp, Margus, Kanger, Tõnis
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 19-02-2010
• Subjects: Catalysis; Catalysts: preparations and properties; Chemistry; Exact sciences and technology; General and physical chemistry; Heterocyclic compounds; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; Kinetics and mechanisms; Organic chemistry; Preparations and properties; Reactivity and mechanisms; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; Nitro compound; Catalytic reaction; Enantioselectivity; Mild operating conditions; Nitrogen heterocycle; Piperidine derivatives; Copper II Acetate; Catalyst; Aldol condensation; Hydrates; Henry reaction
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/jo902664v

A complex derived from the enantiomeric bipiperidine and copper(II) acetate hydrate is an efficient catalyst for the enantioselective Henry reaction. The easy availability of both catalyst components, mild reaction conditions, high yield, and good to excellent enantioselectivity make the catalyst useful for everyday practice.