18F Stilbenes and Styrylpyridines for PET Imaging of Aβ Plaques in Alzheimer’s Disease: A Miniperspective

• Published in: Journal of medicinal chemistry Vol. 53; no. 3; pp. 933 - 941
• Main Authors: Kung, Hank F, Choi, Seok Rye, Qu, Wenchao, Zhang, Wei, Skovronsky, Daniel
• Format: Journal Article
• Language: English
• Published: Columbus, OH American Chemical Society 11-02-2010
• Subjects: Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Amyloid beta-Peptides - metabolism; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Contrast media. Radiopharmaceuticals; Fluorine Radioisotopes - pharmacokinetics; Humans; Medical sciences; Miniperspective; Neuropharmacology; Pharmacology. Drug treatments; Plaque, Amyloid - diagnostic imaging; Plaque, Amyloid - metabolism; Positron-Emission Tomography; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Pyridines - pharmacokinetics; Stilbenes - pharmacokinetics; Styrenes - pharmacokinetics; Tissue Distribution; Fluorine 18; Alzheimer disease; Central nervous system; Binding site; Review; Oligomer; Pyridine derivatives; Scintigraphic agent; Styrene derivatives; Degenerative disease; Chemical synthesis; Nervous system diseases; Fluorine Isotopes; Ether; Radiolabelling; Single photon emission tomography; Benzothiazole derivatives; Biological activity; Stilbene derivatives; Cerebral disorder; β Amyloid protein; Central nervous system disease; Detection; Positron emission tomography; Aromatic amine
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm901039z