Diastereomeric Quinolinone Alkaloids from the Marine-Derived Fungus Penicillium j anczewskii

Diastereomeric Quinolinone Alkaloids from the Marine-Derived Fungus Penicillium j anczewskii

From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S*,4R*-dihydroxy-4-(4‘-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R*,4R*-dihydroxy-4-(4‘-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, pe...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) Vol. 68; no. 9; pp. 1397 - 1399
Main Authors: He, Jian, Lion, Ulrich, Sattler, Isabel, Gollmick, Friedrich A., Grabley, Susanne, Cai, Jingmin, Meiners, Marinus, Schünke, Henning, Schaumann, Karsten, Dechert, Ute, Krohn, Michael
Format: Journal Article
Language:English
Published: American Chemical Society 23-09-2005
Online Access:Get full text
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Summary:From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S*,4R*-dihydroxy-4-(4‘-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R*,4R*-dihydroxy-4-(4‘-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4‘-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np058018g