Minutosides A and B, Antifungal Sulfated Steroid Xylosides from the Patagonian Starfish Anasterias m inuta

Minutosides A and B, Antifungal Sulfated Steroid Xylosides from the Patagonian Starfish Anasterias m inuta

Two new sulfated polyhydroxylated steroidal xylosides, minutosides A (1) and B (2), together with the known pycnopodioside B (3), have been isolated from the brine shrimp active fraction of the ethanolic extract of the starfish Anasterias minuta. The structures have been elucidated by extensive 1D a...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) Vol. 68; no. 8; pp. 1279 - 1283
Main Authors: Chludil, Hugo D, Maier, Marta S
Format: Journal Article
Language:English
Published: American Chemical Society 26-08-2005
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Summary:Two new sulfated polyhydroxylated steroidal xylosides, minutosides A (1) and B (2), together with the known pycnopodioside B (3), have been isolated from the brine shrimp active fraction of the ethanolic extract of the starfish Anasterias minuta. The structures have been elucidated by extensive 1D and 2D NMR as well as FABMS analysis and chemical methods. Compound 2 is the first example of a polyhydroxylated steroidal xyloside containing an amide function in the aglycon side chain. The three xylosides exhibited antifungal activity against Cladosporium cucumerinum and Aspergillus flavus.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050086f