Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade

Polyamines are known to play a significant role in cancer progression and treatment using difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, has shown some clinical promise. It is interesting to note that, while DFMO is directly cytostatic in vitro, recent work has suggested tha...

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Bibliographic Details

Published in:	Journal of immunotherapy (1997)
Main Authors:	Dryja, Parker, Fisher, Carrie, Woster, Patrick M., Bartee, Eric
Format:	Journal Article
Language:	English
Published:	Wolters Kluwer Health, Inc. All rights reserved 16-06-2021
Online Access:	Get full text
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