MET基因改变的非小细胞肺癌靶向治疗耐药机制及治疗策略
间质表皮转化因子(mesenchymal to epithelial transition factor,MET)基因改变参与了非小细胞肺癌的增殖、侵袭和转移.MET-酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)已获批用于MET基因改变的非小细胞肺癌,而这些药物的耐药不可避免.MET-TKIs的分子耐药机制错综复杂,尚不完全清楚.本文主要对这些MET-TKIs的潜在耐药机制进行综述,以期为MET基因改变的患者提供合理的治疗思路....
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| Published in: | 中国肺癌杂志 Vol. 26; no. 9; pp. 684 - 691 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | Chinese |
| Published: |
300060 天津,天津医科大学肿瘤医院生物治疗科,国家恶性肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津市恶性肿瘤临床医学研究中心,天津市肿瘤免疫与生物治疗重点实验室
2023
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| Abstract | 间质表皮转化因子(mesenchymal to epithelial transition factor,MET)基因改变参与了非小细胞肺癌的增殖、侵袭和转移.MET-酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)已获批用于MET基因改变的非小细胞肺癌,而这些药物的耐药不可避免.MET-TKIs的分子耐药机制错综复杂,尚不完全清楚.本文主要对这些MET-TKIs的潜在耐药机制进行综述,以期为MET基因改变的患者提供合理的治疗思路. |
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| AbstractList | 间质表皮转化因子(mesenchymal to epithelial transition factor,MET)基因改变参与了非小细胞肺癌的增殖、侵袭和转移.MET-酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)已获批用于MET基因改变的非小细胞肺癌,而这些药物的耐药不可避免.MET-TKIs的分子耐药机制错综复杂,尚不完全清楚.本文主要对这些MET-TKIs的潜在耐药机制进行综述,以期为MET基因改变的患者提供合理的治疗思路. |
| Author | 李舒展 张新伟 |
| AuthorAffiliation | 300060 天津,天津医科大学肿瘤医院生物治疗科,国家恶性肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津市恶性肿瘤临床医学研究中心,天津市肿瘤免疫与生物治疗重点实验室 |
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| Author_FL | Xinwei ZHANG Shuzhan LI |
| Author_FL_xml | – sequence: 1 fullname: Shuzhan LI – sequence: 2 fullname: Xinwei ZHANG |
| Author_xml | – sequence: 1 fullname: 李舒展 – sequence: 2 fullname: 张新伟 |
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| DOI | 10.3779/j.issn.1009-3419.2023.102.33 |
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| DocumentTitle_FL | Drug Resistance Mechanism and Therapeutic Strategy of Targeted Therapy of Non-small Cell Lung Cancer with MET Alterations |
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| Keywords | Treatment strategy 靶向治疗 Targeted therapy 间质表皮转化因子 肺肿瘤 Drug resistance Mesenchymal to epithelial transition factor 治疗策略 耐药 Lung neoplasms |
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| Title | MET基因改变的非小细胞肺癌靶向治疗耐药机制及治疗策略 |
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