SUMO特异性蛋白酶家族与肿瘤生物学行为的关系
R73; SUMO化修饰是一个动态可逆的过程,需要特异性连接酶参与,其逆反应(去SUMO化)则是由一组SUMO特异性蛋白酶(SUMO-specific proteases,SENPs)参与的催化解离.SUMO化修饰的靶蛋白分子与机体的发育、疾病,特别是肿瘤、代谢、炎症与免疫等密切相关,且SENPs在SUMO蛋白的加工成熟和靶蛋白去SUMO化修饰中发挥重要作用.该文就SENPs家族蛋白在肿瘤发生发展中的作用和机制进行综述....
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| Published in: | 上海交通大学学报（医学版） Vol. 38; no. 3; pp. 348 - 352 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | Chinese |
| Published: |
上海交通大学医学院,上海,200025%上海交通大学基础医学院生物化学与细胞生物学系,上海,200025
2018
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| Online Access: | Get full text |
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| Abstract | R73; SUMO化修饰是一个动态可逆的过程,需要特异性连接酶参与,其逆反应(去SUMO化)则是由一组SUMO特异性蛋白酶(SUMO-specific proteases,SENPs)参与的催化解离.SUMO化修饰的靶蛋白分子与机体的发育、疾病,特别是肿瘤、代谢、炎症与免疫等密切相关,且SENPs在SUMO蛋白的加工成熟和靶蛋白去SUMO化修饰中发挥重要作用.该文就SENPs家族蛋白在肿瘤发生发展中的作用和机制进行综述. |
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| AbstractList | R73; SUMO化修饰是一个动态可逆的过程,需要特异性连接酶参与,其逆反应(去SUMO化)则是由一组SUMO特异性蛋白酶(SUMO-specific proteases,SENPs)参与的催化解离.SUMO化修饰的靶蛋白分子与机体的发育、疾病,特别是肿瘤、代谢、炎症与免疫等密切相关,且SENPs在SUMO蛋白的加工成熟和靶蛋白去SUMO化修饰中发挥重要作用.该文就SENPs家族蛋白在肿瘤发生发展中的作用和机制进行综述. |
| Abstract_FL | SUMOylation is a dynamically reversible process that needs to be modified by a specific ligase, while its inverse reaction deSUMOylation is catalyzed by a group of SUMO-specific proteases (SENPs). SUMO-modified target protein molecules are closely related to development and disease, especially tumor, metabolism, inflammation and immunity. SENPs play an important role in SUMO protein maturation and deSUMOylation. This review discussed the functions of SENPs in the development and progression of tumors and related mechanisms. |
| Author | 李文博 黄答 左勇 李维娅 刘子豪 缪慧娴 |
| AuthorAffiliation | 上海交通大学医学院,上海,200025%上海交通大学基础医学院生物化学与细胞生物学系,上海,200025 |
| AuthorAffiliation_xml | – name: 上海交通大学医学院,上海,200025%上海交通大学基础医学院生物化学与细胞生物学系,上海,200025 |
| Author_FL | MIAO Hui-xian LI Wen-bo ZUO Yong HUANG Da LIU Zi-hao LI Wei-ya |
| Author_FL_xml | – sequence: 1 fullname: MIAO Hui-xian – sequence: 2 fullname: LIU Zi-hao – sequence: 3 fullname: LI Wei-ya – sequence: 4 fullname: HUANG Da – sequence: 5 fullname: LI Wen-bo – sequence: 6 fullname: ZUO Yong |
| Author_xml | – sequence: 1 fullname: 缪慧娴 – sequence: 2 fullname: 刘子豪 – sequence: 3 fullname: 李维娅 – sequence: 4 fullname: 黄答 – sequence: 5 fullname: 李文博 – sequence: 6 fullname: 左勇 |
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| DOI | 10.3969/j.issn.1674-8115.2018.03.020 |
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| DocumentTitle_FL | Role of SUMO-specific proteases in tumor biological behavior |
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| Keywords | SUMO 肿瘤 tumor SUMO特异性蛋白酶 SUMO-specific proteases (SENPs) |
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| PublicationYear | 2018 |
| Publisher | 上海交通大学医学院,上海,200025%上海交通大学基础医学院生物化学与细胞生物学系,上海,200025 |
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| Title | SUMO特异性蛋白酶家族与肿瘤生物学行为的关系 |
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