MEK基因多态性与抑郁症的关联性研究
R749.41%Q78; 目的 研究抑郁症患者丝裂原活化蛋白激酶/细胞外信号调节激酶激酶(MEK)基因的单核苷酸多态性(SNP),探讨MEK基因与抑郁症发病的关联性.方法 采集抑郁症患者(n=425)和健康对照者(n=404)的外周静脉血,提取基因组DNA,采用TaqMan探针SNP基因分型技术,检测两组受试者MEK1基因(rs1549854和rs4255740位点)和MEK2基因(rs7258366和rs12459484位点)4个SNP位点的基因型,并分析基因多态性与抑郁症的关系.结果 ①抑郁症组和对照组在rs1549854位点的基因型和等位基因频率比较,差异有统计学意义(P<0.05...
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| Published in: | 上海交通大学学报（医学版） Vol. 30; no. 6; pp. 616 - 619 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | Chinese |
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上海交通大学,医学院附属精神卫生中心,心境障碍科,上海,200030%上海交通大学,医学院附属精神卫生中心,遗传研究室,上海,200030
2010
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| Abstract | R749.41%Q78; 目的 研究抑郁症患者丝裂原活化蛋白激酶/细胞外信号调节激酶激酶(MEK)基因的单核苷酸多态性(SNP),探讨MEK基因与抑郁症发病的关联性.方法 采集抑郁症患者(n=425)和健康对照者(n=404)的外周静脉血,提取基因组DNA,采用TaqMan探针SNP基因分型技术,检测两组受试者MEK1基因(rs1549854和rs4255740位点)和MEK2基因(rs7258366和rs12459484位点)4个SNP位点的基因型,并分析基因多态性与抑郁症的关系.结果 ①抑郁症组和对照组在rs1549854位点的基因型和等位基因频率比较,差异有统计学意义(P<0.05);两组女性受试者比较差异仍有统计学意义(P<0.01).②对MEK1和MEK2基因的2个位点分别进行基因型联合分析和疾病风险度分析,发现抑郁症组中rs1549854 AA-rs4255740 CC和rs7258366 AA-rs12459484 GG的联合基因型分布频率均显著高于对照组,且后者危险度最高(OR=2.175,P<0.01);而抑郁症组中rs1549854 CC-rs4255740 CT和rs7258366 GG-rs12459484 GG联合基因型分布频率均显著低于对照组,且后者危险度最低(OR=0.132,P<0.01).结论 ①MEK1基因的rs1549854位点可能参与了抑郁症尤其是女性抑郁症的发病.②MEK1/2基因的rs1549854 AA-rs4255740 CC和rs7258366 AA-rs12459484 GG联合基因型可能是抑郁症发病的危险因子,而rs1549854 CC-rs4255740 CT和rs7258366 GG-rs12459484 GG联合基因型可能是抑郁症的保护因子. |
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| AbstractList | R749.41%Q78; 目的 研究抑郁症患者丝裂原活化蛋白激酶/细胞外信号调节激酶激酶(MEK)基因的单核苷酸多态性(SNP),探讨MEK基因与抑郁症发病的关联性.方法 采集抑郁症患者(n=425)和健康对照者(n=404)的外周静脉血,提取基因组DNA,采用TaqMan探针SNP基因分型技术,检测两组受试者MEK1基因(rs1549854和rs4255740位点)和MEK2基因(rs7258366和rs12459484位点)4个SNP位点的基因型,并分析基因多态性与抑郁症的关系.结果 ①抑郁症组和对照组在rs1549854位点的基因型和等位基因频率比较,差异有统计学意义(P<0.05);两组女性受试者比较差异仍有统计学意义(P<0.01).②对MEK1和MEK2基因的2个位点分别进行基因型联合分析和疾病风险度分析,发现抑郁症组中rs1549854 AA-rs4255740 CC和rs7258366 AA-rs12459484 GG的联合基因型分布频率均显著高于对照组,且后者危险度最高(OR=2.175,P<0.01);而抑郁症组中rs1549854 CC-rs4255740 CT和rs7258366 GG-rs12459484 GG联合基因型分布频率均显著低于对照组,且后者危险度最低(OR=0.132,P<0.01).结论 ①MEK1基因的rs1549854位点可能参与了抑郁症尤其是女性抑郁症的发病.②MEK1/2基因的rs1549854 AA-rs4255740 CC和rs7258366 AA-rs12459484 GG联合基因型可能是抑郁症发病的危险因子,而rs1549854 CC-rs4255740 CT和rs7258366 GG-rs12459484 GG联合基因型可能是抑郁症的保护因子. |
| Author | 汪栋祥 李则挚 张晨 胡莺燕 禹顺英 曹岚 陈俊 洪武 苑成梅 吴志国 易正辉 黄佳 方贻儒 |
| AuthorAffiliation | 上海交通大学,医学院附属精神卫生中心,心境障碍科,上海,200030%上海交通大学,医学院附属精神卫生中心,遗传研究室,上海,200030 |
| AuthorAffiliation_xml | – name: 上海交通大学,医学院附属精神卫生中心,心境障碍科,上海,200030%上海交通大学,医学院附属精神卫生中心,遗传研究室,上海,200030 |
| Author_FL | HU Ying-yan HONG Wu YUAN Cheng-mei HUANG Jia FANG Yi-ru ZHANG Chen WANG Dong-xiang YU Shun-ying YI Zheng-hui WU Zhi-guo CHEN Jun LI Ze-zhi CAO Lan |
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| Keywords | 丝裂原活化蛋白激酶/细胞外信号调节激酶激酶 抑郁症 单核苷酸多态性 |
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| Publisher | 上海交通大学,医学院附属精神卫生中心,心境障碍科,上海,200030%上海交通大学,医学院附属精神卫生中心,遗传研究室,上海,200030 |
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| Title | MEK基因多态性与抑郁症的关联性研究 |
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