Bisphenol (A) uremic toxin to take into account in the Renal disease in Hemodialysis

• Published in: Revista colombiana de nefrología (En línea) Vol. 4; no. 1; pp. 57 - 68
• Main Authors: Bosch-Panadero, Enrique, Mas Fontao, Sebastián, Ruiz Priego, Alberto, Egido, Jesús, González Parra, Emilio
• Format: Journal Article
• Language: Portuguese
• Published: Asociación Colombiana de Nefrología e Hipertensión Arterial 01-06-2017
• Subjects: SOCIAL SCIENCES, INTERDISCIPLINARY; Bisphenol A; chronic kidney disease; hemodiálisis; Uremic toxin; hemodialysis; endocrine disruptor; toxina urémica; disruptor endocrino; bisfenol A; enfermedad crónica renal
• ISSN: 2500-5006; 2500-5006
• DOI: 10.22265/acnef.41.256

Abstract Introduction: Most uremic toxins are by-products of protein metabolism by action of intestinal flora. The metabolism of aromatic amino acids originates phenolic type residues. The most studied is p-cresol that is associated with renal function and vascular damage. Bisphenol A (BPA) is an exogenous molecule with characteristics similar to these aromatic uremic toxins. BPA is an estrogenic endocrine disruptor, found in tin cans, plastic bottles, epoxy resins and in some dialyzers. This molecule accumulates in patients who have impaired renal function. Observational studies have shown that exposure of BPA is linked to renal and cardiovascular injury, among many others in humans, and in animal studies a causal link has been described. Kidneys with normal renal function rapidly excrete BPA, but insufficient excretion in patients with CKD results in accumulation of BPA in the body.