Expedient access to an N-phenylpyrrolidin-2-yl heterocycle via a base-induced intramolecular aza-Michael reaction : research article

Expedient access to an N-phenylpyrrolidin-2-yl heterocycle via a base-induced intramolecular aza-Michael reaction : research article

Ethyl 2-(1-phenylpiperidin-2-yl) acetate was formed in a spontaneous cyclization from (E)-ethyl 7-oxohept-2-enoate whereas ethyl [1-(2-bromophenyl)-2-pyrrolidinyl] acetate could be synthesized in good overall yield when employing a stoichiometric amount of base to facilitate the intramolecular aza-M...

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Bibliographic Details
Published in:South African journal of chemistry Vol. 64; no. 1; pp. 225 - 230
Main Authors: Nagem, Tanus J., Ferreira Ramos, Josierika A., Taylor, Jason G.
Format: Journal Article
Language:English
Published: South African Chemical Institute (SACI) 01-01-2011
Subjects:
aza-Michael
Base
Catalysed
Intramolecular
Piperidine
Pyrrolidine
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Summary:Ethyl 2-(1-phenylpiperidin-2-yl) acetate was formed in a spontaneous cyclization from (E)-ethyl 7-oxohept-2-enoate whereas ethyl [1-(2-bromophenyl)-2-pyrrolidinyl] acetate could be synthesized in good overall yield when employing a stoichiometric amount of base to facilitate the intramolecular aza-Michael reaction.
ISSN:0379-4350