Multicomponent synthesis acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines
Herein, we report palladium supported on a hydroxyapatite catalyst for synthesizing tri-substituted pyridines using ammonium acetate as the nitrogen source via acceptorless alcohol dehydrogenation strategy. The strategy offers a broad substrate scope using inexpensive and readily available alcohols...
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| Published in: | RSC advances Vol. 14; no. 15; pp. 1761 - 1767 |
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| Main Author: | |
| Format: | Journal Article |
| Published: |
03-04-2024
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| Online Access: | Get full text |
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| Summary: | Herein, we report palladium supported on a hydroxyapatite catalyst for synthesizing tri-substituted pyridines using ammonium acetate as the nitrogen source
via
acceptorless alcohol dehydrogenation strategy. The strategy offers a broad substrate scope using inexpensive and readily available alcohols as the starting material. The catalyst was prepared using a simple method and analyzed by several techniques, including FE-SEM, EDS, HR-TEM, BET, XRD, FT-IR, UV-visible spectroscopy, and XPS, demonstrating the anchoring of Pd nanoparticles on hydroxyapatite in the zero oxidation state. Moreover, several controlled experiments were carried out to understand the reaction pathway and a suitable mechanism has been proposed.
The multicomponent synthesis of 2,4,6-trisubstituted pyridine
via
acceptorless alcohol dehydrogenation using ammonium acetate as a nitrogen source catalyzed by hydroxyapatite-supported palladium nanoparticles as a heterogeneous catalyst. |
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| Bibliography: | https://doi.org/10.1039/d4ra00439f 1 H NMR, and 13 Electronic supplementary information (ESI) available: General information, experimental procedure, catalyst characterization data C NMR spectral data of all compounds. See DOI |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/d4ra00439f |