Photophysical characterization and fluorescence cell imaging applications of 4--substituted benzothiadiazoles
In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various N -substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correla...
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| Published in: | RSC advances Vol. 12; no. 23; pp. 14544 - 1455 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Published: |
13-05-2022
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| Online Access: | Get full text |
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| Summary: | In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various
N
-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log
P
≥ 4 being characteristic for lipid droplet accumulation.
Herein we report the structure-photophysical relationship and cell imaging utility of a series of
N
-substituted benzothiadiazoles. |
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| Bibliography: | Electronic supplementary information (ESI) available: Experimental details, photophysical and computational data, cell pictures and viability, and NMR spectra. See https://doi.org/10.1039/d2ra01404a |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/d2ra01404a |