Chromosome errors in human eggs shape natural fertility over reproductive lifespan
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions causing pregnancy loss and congenital disorders. Here we have followed chromosome segregation in human oocytes from females aged 9 to 43 years, and report that aneuploidy follows a U-curve. Specific segregatio...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 365; no. 6460; pp. 1466 - 1469 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
27-09-2019
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| Online Access: | Get full text |
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| Abstract | Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions causing pregnancy loss and congenital disorders. Here we have followed chromosome segregation in human oocytes from females aged 9 to 43 years, and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans. |
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| AbstractList | Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions causing pregnancy loss and congenital disorders. Here we have followed chromosome segregation in human oocytes from females aged 9 to 43 years, and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans. |
| Author | Cheng, Junping Newnham, Louise J. Nikiforov, Dmitry Rienzi, Laura McCoy, Rajiv Scarica, Catello Kristensen, Stine Gry Zielinska, Agata P. Capalbo, Antonio Cimadomo, Danilo Hoffmann, Eva R. Elder, Kay Taylor, Deborah Gruhn, Jennifer R. Shukla, Vallari Colmorn, Lotte Berdiin Vogel, Ivan Ubaldi, Filippo Bjørn, Anne-Mette Bay Liss, Joanna Blanshard, Robert Groendahl, Marie Louise Andersen, Claus Yding Schuh, Melina Lukaszuk, Krzysztof Chan, Andrew Chi-Ho Ernst, Erik Krapchev, Marta Hartshorne, Geraldine Blayney, Martyn |
| AuthorAffiliation | 14 Bourn Hall Clinic, Cambridge, UK 1 DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark 8 Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy 4 Illumina Inc., Fulbourn, UK 11 Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK 17 Department of Biology, Johns Hopkins University, Baltimore, MD, USA 12 Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark 7 Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark 9 DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy 5 Igenomix, Marostica, Italy 13 The Fertility Clinic, The Juliane Marie Centre for Women, Childre |
| AuthorAffiliation_xml | – name: 15 Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland – name: 18 Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland – name: 19 Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – name: 5 Igenomix, Marostica, Italy – name: 17 Department of Biology, Johns Hopkins University, Baltimore, MD, USA – name: 9 DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy – name: 14 Bourn Hall Clinic, Cambridge, UK – name: 10 INVICTA Fertility and Reproductive Center, Gdańsk, Poland – name: 2 Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany – name: 8 Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy – name: 4 Illumina Inc., Fulbourn, UK – name: 16 Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark – name: 11 Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK – name: 12 Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark – name: 7 Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark – name: 6 G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy – name: 3 Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK – name: 1 DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark – name: 13 The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark |
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Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 15 givenname: Junping surname: Cheng fullname: Cheng, Junping organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 16 givenname: Erik surname: Ernst fullname: Ernst, Erik organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 17 givenname: Anne-Mette Bay surname: Bjørn fullname: Bjørn, Anne-Mette Bay organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 18 givenname: Lotte Berdiin surname: Colmorn fullname: Colmorn, Lotte Berdiin organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 19 givenname: Martyn surname: Blayney fullname: Blayney, Martyn organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 20 givenname: Kay surname: Elder fullname: Elder, Kay organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 21 givenname: Joanna surname: Liss fullname: Liss, Joanna organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 22 givenname: Geraldine surname: Hartshorne fullname: Hartshorne, Geraldine organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 23 givenname: Marie Louise surname: Groendahl fullname: Groendahl, Marie Louise organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 24 givenname: Laura surname: Rienzi fullname: Rienzi, Laura organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 25 givenname: Filippo surname: Ubaldi fullname: Ubaldi, Filippo organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 26 givenname: Rajiv surname: McCoy fullname: McCoy, Rajiv organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 27 givenname: Krzysztof surname: Lukaszuk fullname: Lukaszuk, Krzysztof organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 28 givenname: Claus Yding surname: Andersen fullname: Andersen, Claus Yding organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 29 givenname: Melina surname: Schuh fullname: Schuh, Melina organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland – sequence: 30 givenname: Eva R. surname: Hoffmann fullname: Hoffmann, Eva R. email: eva@sund.ku.dk organization: DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK Illumina Inc., Fulbourn, UK Igenomix, Marostica, Italy G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197, Rome, Italy Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy INVICTA Fertility and Reproductive Center, Gdańsk, Poland Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark Bourn Hall Clinic, Cambridge, UK Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark Department of Biology, Johns Hopkins University, Baltimore, MD, USA Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland |
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| ContentType | Journal Article |
| DBID | 5PM |
| DOI | 10.1126/science.aav7321 |
| DatabaseName | PubMed Central (Full Participant titles) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Biology |
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| Snippet | Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions causing pregnancy loss and congenital disorders. Here we have... |
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| Title | Chromosome errors in human eggs shape natural fertility over reproductive lifespan |
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