Consistency of drug profiles and predictors in large-scale cancer cell line data

Consistency of drug profiles and predictors in large-scale cancer cell line data

Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here, we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two...

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Bibliographic Details
Published in:Nature (London) Vol. 528; no. 7580; pp. 84 - 87
Main Authors: Stransky, Nicolas, Ghandi, Mahmoud, Kryukov, Gregory V., Garraway, Levi A., Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Haber, Daniel A., Ramaswamy, Sridhar, Benes, Cyril H., Lehár, Joseph, Liu, Manway, Sonkin, Dmitriy, Kauffmann, Audrey, Venkatesan, Kavitha, Edelman, Elena J., Riester, Markus, Barretina, Jordi, Caponigro, Giordano, Schlegel, Robert, Sellers, William, Stegmeier, Frank, Morrissey, Michael, Menden, Michael P., Iorio, Francesco, Stratton, Michael R., McDermott, Ultan, Saez-Rodriguez, Julio, Garnett, Mathew J.
Format: Journal Article
Language:English
Published: 16-11-2015
Online Access:Get full text
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Summary:Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here, we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer.
Bibliography:current contact information: Blueprint Medicines, Cambridge, MA
ISSN:0028-0836
1476-4687
DOI:10.1038/nature15736