Access to Electron-Rich Arene-Fused Hexahydroquinolizinones via A Gold Catalysis-Triggered Cascade Process

Access to Electron-Rich Arene-Fused Hexahydroquinolizinones via A Gold Catalysis-Triggered Cascade Process

Golden Cascade? Using a tethered, electron-rich arene as the internal nucleophile, a gold catalyzed amide cyclization to an alkyne serves as the trigger of a cascade process that ends with a Ferrier rearrangement. Electron-rich arene-fused hexahydroqinolizin-2-ones are formed in good yields and can...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 51; no. 29; pp. 7301 - 7304
Main Authors: Liu, Lianzhu, Zhang, Liming
Format: Journal Article
Language:English
Published: 12-06-2012
Online Access:Get full text
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Summary:Golden Cascade? Using a tethered, electron-rich arene as the internal nucleophile, a gold catalyzed amide cyclization to an alkyne serves as the trigger of a cascade process that ends with a Ferrier rearrangement. Electron-rich arene-fused hexahydroqinolizin-2-ones are formed in good yields and can be converted into indole alkaloids in short orders.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203303