Induction of cytochrome P450 and vitamin A. Study in swine under the influence of DDT

DDT induces in young Pigs a rise of hepatic level of cytochrome P 450 and a concomitant decrease of the hepatic "reserve" of retinol. The amplitude of these effects varies according to the hepatic lobe submitted to analysis.

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Bibliographic Details
Published in:	Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles Vol. 282; no. 16; p. 1561
Main Authors:	Graillot, C, Gak, C, Ferrando, R, Truhaut, R
Format:	Journal Article
Language:	French
Published:	France 26-04-1976
Subjects:	Animals Cytochrome P-450 Enzyme System - biosynthesis DDT - pharmacology Liver - drug effects Liver - metabolism Male Organ Size Swine Vitamin A - metabolism
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Description
Summary:	DDT induces in young Pigs a rise of hepatic level of cytochrome P 450 and a concomitant decrease of the hepatic "reserve" of retinol. The amplitude of these effects varies according to the hepatic lobe submitted to analysis.