Results of Lucia Keratoprosthesis Implantation in Severe Corneal Disease.: Results of Lucia KPro

• Published in: American journal of ophthalmology
• Main Authors: Ortiz-Morales, Gustavo, Vera-Duarte, Guillermo Raul, Jimenez-Collado, David, Arteaga-Rivera, Jose, Arteaga-Rivera, Karla, Domene-Hickman, Jorge Luis, Müller-Morales, Carlos Adolfo, Navas, Alejandro, Ramirez-Miranda, Arturo, Chodosh, James, Graue-Hernandez, Enrique O
• Format: Journal Article
• Language: English
• Published: United States 05-09-2024
• Subjects: Corneal transplantation; Lucia KPro; Keratoplasty; Keratoprosthesis; Boston KPro; Primary KPro
• ISSN: 1879-1891

Describe complications, functional success, and retention of the Lucia Keratoprosthesis (KPro).
Retrospective interventional case series METHODS: The demographic data, baseline characteristics, complications, functional success, and retention were analyzed for Lucia KPro at Instituto de Oftalmologia Conde de Valenciana in Mexico City from 2021-2023. Multivariate regression analysis and Kaplan-Meier plots were performed to identify associations with functional failure. The main outcome measures were postoperative complications; functional success defined as best-corrected visual acuity (BCVA) ≥ 20/200 (LogMAR 1.0); and device retention rate.
Forty-eight eyes of 48 patients (56.88% male) were studied. The mean age at implantation was 57.29 ± 15.63 years (range 27-91) with a mean follow-up of 20.5 ± 8.83 months (range: 3-40). Diagnostic indications for implantation included recurrent graft rejection (54.17%), autoimmune disease (20.83%), chemical injury (12.5%), and other (12.5%). At least one postoperative complication occurred in 75% of patients leading to 65 additional interventions (mean number of subsequent procedures: 1.35 ± 1.3, range 0-5). The preoperative BCVA was 2.40 ± 0.36 LogMAR. At the final follow-up, 62.5% had achieved functional success and 22.92% had a BCVA of 20/40 (LogMAR 0.3) or better. Glaucoma (adjusted OR: 469.74, 95% CI 5.02 - 43939.14, p=0.007) and retinal pathology before KPro (adjusted OR: 372.38, 95% CI 4.18 - 33162.11, p=0.009) were associated with functional failure. The device remained in place in 95.83% of recipients over the follow-up period.
The Lucia KPro offers functional success in severe corneal diseases and excellent retention in the short to intermediate term.