Alveolar Type II Cell Damage and Nrf2-SOD1 Pathway Downregulation Are Involved in PM 2.5 -Induced Lung Injury in Rats

The general toxicity of fine particulate matter (PM ) has been intensively studied, but its pulmonary toxicities are still not fully understood. To investigate the changes of lung tissue after PM exposure and identify the potential mechanisms of pulmonary toxicity, PM samples were firstly collected...

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Bibliographic Details
Published in:	International journal of environmental research and public health Vol. 19; no. 19
Main Authors:	Niu, Rui, Cheng, Jie, Sun, Jian, Li, Fan, Fang, Huanle, Lei, Ronghui, Shen, Zhenxing, Hu, Hao, Li, Jianjun
Format:	Journal Article
Language:	English
Published:	Switzerland 08-10-2022
Subjects:	8-Hydroxy-2'-Deoxyguanosine Ammonium Compounds Animals Antioxidants - metabolism Carbon - metabolism Catalase - metabolism Down-Regulation Lung - metabolism Lung Diseases Lung Injury - chemically induced NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nitrates - metabolism Oxidative Stress Particulate Matter Rats Reactive Oxygen Species - metabolism Sulfates - metabolism Superoxide Dismutase - metabolism Superoxide Dismutase-1 - metabolism lung injury PM2.5 constituents alveolar type II cells PM2.5 oxidative stress
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