Memantine improves cognitive deficits via K ATP channel inhibition in olfactory bulbectomized mice

Patients with Alzheimer's disease (AD) demonstrate severely impaired olfactory systems, which occur in the early stages of the disease. Olfactory bulbectomy (OBX) in mice elicits cognitive deficits, and reduces cholinergic activity in the hippocampus. Here, we confirmed that the novel AD drug m...

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Bibliographic Details

Published in:	Molecular and cellular neuroscience Vol. 117; p. 103680
Main Authors:	Moriguchi, Shigeki, Inagaki, Ryo, Fukunaga, Kohji
Format:	Journal Article
Language:	English
Published:	United States 01-12-2021
Subjects:	Adenosine Triphosphate Animals Cognition Hippocampus Humans Long-Term Potentiation Memantine - pharmacology Mice Olfactory Bulb - surgery OBX mice CaMKII Memantine CaMKIV Cognitive deficits K(ATP) channel
Online Access:	Get full text
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