Modifying the m 6 A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapses. However how RNA is regulated, and which transcr...

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Bibliographic Details

Published in:	Molecular psychiatry Vol. 26; no. 12; p. 7141
Main Authors:	Martinez De La Cruz, Braulio, Markus, Robert, Malla, Sunir, Haig, Maria Isabel, Gell, Chris, Sang, Fei, Bellows, Eleanor, Sherif, Mahmoud Awad, McLean, Denise, Lourdusamy, Anbarasu, Self, Tim, Bodi, Zsuzsanna, Smith, Stuart, Fay, Michael, Macdonald, Ian A, Fray, Rupert, Knight, Helen Miranda
Format:	Journal Article
Language:	English
Published:	England 01-12-2021
Subjects:	AlkB Homolog 5, RNA Demethylase - genetics AlkB Homolog 5, RNA Demethylase - metabolism Brain - metabolism Demethylation Epigenome Humans Neuronal Plasticity - physiology Synapses - metabolism
Online Access:	Get full text
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