Prostaglandin E 2 induces dual-specificity phosphatase-1, thereby attenuating inflammatory genes expression in human osteoarthritic synovial fibroblasts

Characteristic features of osteoarthritis (OA) are joint pain and cartilage degeneration. The degeneration is caused by excess induction of matrix metalloproteinases (MMPs) and the pain is caused by nerve growth factor (NGF)-dependent nerve invasion into synovial tissue in addition to nociceptive pa...

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Bibliographic Details
Published in:	Prostaglandins & other lipid mediators Vol. 154; p. 106550
Main Authors:	Maekawa, Asato, Sawaji, Yasunobu, Endo, Kenji, Kusakabe, Takuya, Konishi, Takamitsu, Tateiwa, Toshiyuki, Masaoka, Toshinori, Shishido, Takaaki, Yamamoto, Kengo
Format:	Journal Article
Language:	English
Published:	United States 01-06-2021
Subjects:	Cells, Cultured Dinoprostone - metabolism Dual Specificity Phosphatase 1 - genetics Dual Specificity Phosphatase 1 - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation - drug effects Humans Interleukin-1beta - metabolism Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - pathology Phosphorylation - drug effects Synovial Membrane - drug effects Synovial Membrane - metabolism Synovial Membrane - pathology Pain Matrix degeneration Inflammation Prostaglandin E Osteoarthritis Synovium
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