Glucocorticoid Receptor Activation Restores Learning Memory by Modulating Hippocampal Plasticity in a Mouse Model of Brain Vitamin B 12 Deficiency

Cobalamin (Cbl, vitamin B ) deficiency or inborn errors of Cbl metabolism can produce neurologic disorders resistant to therapies, including cognitive dysfunction, mild mental retardation, memory impairment, and confusion. We used Cd320 KO mouse as a model for studying the pathological mechanisms of...

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Bibliographic Details
Published in:	Molecular neurobiology Vol. 58; no. 3; p. 1024
Main Authors:	Dreumont, Natacha, Mimoun, Khalid, Pourié, Carine, Quadros, Edward V, Alberto, Jean-Marc, Umoret, Rémy, Helle, Déborah, Robert, Aurélie, Daval, Jean-Luc, Guéant, Jean-Louis, Pourié, Grégory
Format:	Journal Article
Language:	English
Published:	United States 01-03-2021
Subjects:	Animals Behavior, Animal - drug effects Brain - physiopathology Cognition - drug effects Disease Models, Animal Glucocorticoids - pharmacology Hippocampus - drug effects Hippocampus - physiopathology Hydrocortisone - administration & dosage Hydrocortisone - pharmacology Male Memory Mice Mice, Knockout Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Receptors, Cell Surface - deficiency Receptors, Cell Surface - metabolism Receptors, Glucocorticoid - metabolism Signal Transduction - drug effects Stress, Physiological - drug effects Vitamin B 12 Deficiency - physiopathology Signal transduction Synapse Cognition Behavior Vitamin B12
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